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작성자 Matilda 작성일23-06-17 22:39 조회35회 댓글0건

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Aplastic Anemia and MDS International Foundation

The Aplastic Anemia & MDS International Foundation supports patients and their families who are affected by Aplastic anemia (aplastic anemia), myelodysplastic syndrome (MDS) and paroxysmal hemoglobinuria that occurs at night. The Foundation also studies bone marrow dysfunction diseases and related conditions.

Diesel exhaust is a typical exposure for CN railroad employees who work near locomotives or other railway equipment. The exposure can cause occupational lung disease as well as blood disorders.

Causes

Aplastic anemia is caused by the destruction of blood stem cells, which are responsible for the production of blood-forming cells (red blood cells white blood cells, platelets). This means that bone marrow does not produce enough healthy blood cells. This is a serious problem and can be life-threatening.

Aplastic anemia may be caused by radiation and chemotherapy treatments that treat cancer. These treatments can damage stem cells that reside in bone marrow. This kind of aplastic anemia usually improves when these treatments are completed.

This condition is often caused by occupational exposure to diesel exhaust. Diesel exhaust can trigger respiratory issues, blood disorders and other health issues for railroad workers.

These medications, such as colony stimulating factors (sargramostim or leucovorin), can stimulate bone marrow and help prevent anemia. These drugs are often utilized in conjunction with immune suppressing medications, such as cyclosporine, Neoral, Sandimmune, and anti-thymocyte-globulin. For those with autoimmune-related aplastic anemia, avoiding insecticides, herbicides, organic solvents, paint removers and other harmful chemicals may reduce the risk of developing this disease. Antibiotics can lower your risk. If you contract an infection, your doctor may prescribe high doses of corticosteroids such as methylprednisolone or Medrol.

Diagnosis

Typically doctors will diagnose this condition by looking at your medical history and family history along with a physical exam and tests results. If he suspects that you have this condition it is possible to refer you to a specialist known as a hematologist. He will attempt to determine how serious the condition is and also the reason for it.

A hematologist runs a series tests to detect abnormalities in your blood cells as well as bone. They will perform a complete blood count (CBC) which evaluates the white and red blood cell counts. It also evaluates your hemoglobin levels and hematocrit. These iron-rich proteins transport oxygen to cells in your body. Anemia is indicated by a low hematocrit.

The CBC will also tell you if your immune system functions normally or not. It can also detect enlarged nodes that are an indication of certain types of cancer. A hematologist will also examine your spleen and liver for signs of liver disease or infection.

In addition to these tests, a doctor may require a bone marrow aspiration or biopsy. In this procedure an instrument is used to extract bone marrow fluid and checks it under a microscope to detect defective blood cells. A hematologist can also perform the procedure of a bone marrow transplant if the condition isn't manageable with medication.

Treatment

Diesel exhaust has been linked to aplastic anemia which means train drivers and other railroad workers are at risk. Aplastic anemia can also be caused by benzene which is a chemical present in petroleum-based products such as solvents, paint thinners, degreasers, lubricants and other cleaners. It is also used in glues, inks, rubbers, and inks. People who are exposed to benzene at work, like mechanics refinery and oilfield workers, boilermakers, pressmen and tanker truck drivers are more likely to develop the condition.

These drugs, called immunosuppressants, include cyclosporine (Gengraf, Neoral and Sandimmune) and anti-thymocyte globulin. These medicines, also known as immunosuppressants, include the cyclosporine (Gengraf, Canadian national railway esophageal cancer Neoral, Sandimmune) and anti-thymocyte globulin. Blood transfusions, and certain medications that stimulate bone marrow can also improve symptoms.

Additionally there is research underway to to find a cure for PNH and other bone marrow dysfunction diseases. The Aplastic Anemia and Myelodysplastic Syndrome International Foundation and the canadian national railway scleroderma Organization for Rare Disorders are sponsoring the biggest-ever study on hemoglobinuria with paroxysmal nocturnal manifestations. Other studies will focus on aplastic anemia, myelodysplastic disorder and leukemia. The research will be conducted in various medical centers all over Canada, the United States, and Europe.

Prevention

canadian national railway esophageal Cancer canadian national railway interstitial lung disease Railway, founded on June 6, 1919, is the sole transcontinental rail network in North America. A Crown corporation when it was founded it grew to encompass a variety of companies which included hotels, marine operations, and telecommunications, but its primary focus is railway transportation. Donald Gordon was the dynamic president of CN. He modernized the system, streamlined 80 subsidiaries down to 30, and then converted them to electronic signalling and diesel locomotives. CN Exploration was established to develop CN's mineral rights. CN Real Estate was established to redevelop downtown properties owned by the company in various cities, including the CN Tower.

Diesel exhaust is usually breathed in by workers who construct and maintain canadian national railway chronic obstructive pulmonary disease tracks. Poorly ventilated cabs permit toxic fumes to travel back onto clothing and skin and cause conditions that could lead to occupational cancers, pulmonary issues and blood disorders. Potential donors are encouraged attend local stem cell registry drive such as the one that is taking place this week, at St. Matthews High School located at 6550 Bilberry Drive. Those who are matches will be contacted to schedule further testing.

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