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작성자 Dorie 작성일23-06-17 23:42 조회17회 댓글0건

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Esophageal Cancer (EAC) and Esophageal Sarcoma (ESCC) in Canada

Since the mid-1980s, EAC rates have increased in Canada while ESCC rates have declined. These opposite trends could be the result of the changing patterns of smoking cigarettes and Injury Settlement diet, as well as other factors.

Five-year relative survival of patients diagnosed with esophageal tumors is low (13 percent). The rate of survival varies based on the morphology of the tumor and its the location.

Risk Factors

Esophageal cancer is the leading cause of cancer-related deaths worldwide with more than 604,000 new cases and 544,000 deaths in 2017. Approximately 70 percent of cases are diagnosed in men, and are more prevalent among older people. The incidence and mortality rates vary by region. The highest rates are in Eastern Asia (especially China) while the lowest rates are in Western sub-Saharan Africa.

Overall, the global age-standardised incidence, mortality and DALY rates for esophageal squamous cell carcinoma (ESCC) have been decreasing since 1990; however, this trend is not consistent across all countries/territories. These changes are largely a result of improved diagnosis and treatment, but they also reflect the changing environment around us, with increased exposure to alcohol and smoking tobacco.

Additionally, a variety of risk factors contribute to the development of esophageal-adenocarcinoma (EAC). This includes an underlying history of gastro-oesophageal disease, long-term cigarette or alcohol use, heavy chewing of tobacco, poor oral health; a diet low in fruits and vegetables; and being overweight. Other potential risk factors for EAC include a hereditary predisposition, and the presence of Barrett's esophagus.

The specific esophageal cancer DALY rate is calculated using the country-wide prevalence and incidence rates, as well as a weighting factor specific to the disease to estimate sequelae-specific disability (YLDs). For more information, Injury settlement please refer to the Methodology Section of the Technical Report.

Diagnosis

Incidence and survival rates for esophageal carcinoma are low. In Canada the five-year rate of survival is 13 percent. This is the lowest survival rate.

Esophageal cancers fall into two categories: esophageal Squamous-cell carcinomas (ESCC) or esophageal cancers called adenocarcinomas. Tumors that are located in the upper portion of the esophagus could be classified as squamous cell carcinomas, while those that are located in the lower part of the esophagus could be adenocarcinomas. A biopsy is often required to confirm the diagnosis. The procedure used for this is called an esophagogastroduodenoscopy. It involves passing a flexible camera-equipped tube into the throat to examine the esophageal walls. The biopsy is taken from the lesion, and then tested for malignancy.

Since the mid-1980s, rates of Esophageal carcinoma have been steady in Canada, with EAC rates slightly higher than ESCC. Between 1986 and 2006, the rate of EAC increased by two-thirds while ESCC decreased by a third. The increase in EAC could be due to obesity and gastroesophageal reflux disease. The decrease in ESCC is most likely the result of decreased smoking.

The rates of survival and incidence vary across the United States, based on the type of tumor and the location of the anatomical. For example, EAC rates have increased significantly in British Columbia, Ontario and Quebec, whereas ESCC rates have decreased.

Treatment

The cancer may be in the cells' outer layer (squamous cell carcinoma), or connective tissue and muscle on the inside (esophageal squamous cancer). These kinds of cancers can be treated surgically. It is more difficult for the cancer to be cured if it has spread to nearby lymph nodes and tissues. Endoscopic ablation and injury settlement radiation therapy are options for patients with stage II esophageal carcinoma. They also require a close follow-up with endoscopy, to check for any signs of the cancer recurring.

Chemotherapy is the process of using medications to stop cancer cells from growing or kill them. The drugs can be taken by mouth or in a vein or muscle. They can be administered with or without radiation. When chemotherapy is given using radiation, it is known as Chemoradiation Therapy.

A tube made of plastic can be placed into the esophagus in order to keep it open during radiation treatment. This is known as a gastrostomy tube. It is essential to keep the esophagus open since swallowing can stop pneumonia from occurring.

Targeted therapy uses medicines to attack specific cancer cells and minimize the side effects of chemotherapy or radiation therapy. These medicines may include monoclonal antibodies and other medications. There are currently clinical trials in progress to discover new treatments for cancers of the esophagus.

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