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작성자 Zelda 작성일23-06-12 01:00 조회17회 댓글0건

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Esophageal Cancer (EAC) and Esophageal Sarcoma (ESCC) in Canada

Since the mid-1980s, EAC rates have increased in Canada while ESCC rates have declined. These contradictory trends could be a result of changes in the patterns of smoking cigarettes and diet, as well as other factors.

The five-year survival rate for those diagnosed with esophageal tumor is low (13 percent). The odds vary based on the morphology and location.

Risk Factors

Esophageal cancer is the leading cause of cancer-related deaths worldwide with more than 604,000 newly diagnosed cases and 544,000 deaths in 2017. About 70 percent of cases are diagnosed in men and are generally more prevalent among older people. Incidence and mortality rates vary by region, with high levels in Eastern Asia (particularly China) and lower levels in Western sub-Saharan Africa.

Overall, the global age-standardised incidence, mortality and DALY rates for esophageal squamous cell carcinoma (ESCC) have been decreasing since 1990; however, canadian pacific asthma this trend is not consistent across all countries/territories. These changes are partly a result of improved diagnosis and treatment, but they also reflect the changing world environment which has increasing exposure to alcohol and tobacco smoking.

Many other risk factors can be associated with the development of esophageal tumor (EAC). These include a history of gastro-oesophageal reflux disease, Canadian Pacific Asthma long-term cigarette or canadian Pacific asthma alcohol consumption, frequent chewing of tobacco and poor oral health; a diet deficient in vegetables and fruits and canadian pacific black Lung disease being overweight. Other risk factors for Canadian Pacific Kidney Cancer EAC include a hereditary predisposition and the presence of Barrett's esophagus.

The esophageal cancer-specific DALY rate is calculated using the country-level prevalence and incidence rates and a disease-specific weighting factor to calculate sequelae-specific disability (YLDs). For more information, please refer to the Methodology Section of the Technical Report.

Diagnosis

Incidence and survival rates for esophageal cancer are low. In Canada the five-year relative survival is 13 percent. This is one of the lowest survival rates for any cancer.

Esophageal cancers are classified into two categories: canadian pacific emphysema esophageal carcinomas (ESCC) or esophageal Adenocarcinomas. Tumors that are located in the upper part of the esophagus are classified as squamous cell carcinomas and those located in the lower region of the esophagus can be classified as Adenocarcinomas. Usually it is necessary to take a biopsy to confirm the diagnosis. The procedure used for this is called an esophagogastroduodenoscopy. It involves passing a flexible camera-equipped tube through the throat in order to look at the esophageal wall. The biopsy is then taken from the lesion in order to test for malignancy.

Since the mid-1980s, the rates of esophageal carcinoma have been stable in Canada The most notable difference is EAC rates slightly higher than ESCC. Between 1986 and 2006 the prevalence of EAC increased by two-thirds while ESCC decreased by a third. The increase in the prevalence of EAC could be due in part to the increase in gastroesophageal disease and obesity. The decrease in ESCC is likely a result of decreased smoking.

The rates of survival and incidence differ across the country based on the tumour morphology, anatomical location and other factors. For example, EAC rates have increased significantly in British Columbia, Ontario and Quebec, whereas ESCC rates have decreased.

Treatment

The cancer may be in the cells that line the outside (squamous cell carcinoma) or canadian pacific leukemia in connective tissue and muscle on the inside (esophageal squamous tumor). These cancers are often cured through surgery. It is more difficult for the canadian pacific bladder cancer to be eradicated if it has spread to adjacent lymph nodes and tissues. Endoscopic ablation and radiation therapy are two options for those suffering from stage II esophageal cancer. They also require a close follow-up with endoscopy, to check for any signs of cancer returning.

Chemotherapy is the process of using drugs to stop cancerous cells from growing, or kill them. The drugs can be consumed by mouth or in a vein or muscle. They can be administered without or with radiation. When chemotherapy is coupled with radiation, the treatment is called chemotherapy radiotherapy.

To keep the esophagus in a closed position during radiation treatment, a tube made of plastic can be inserted. This is known as a gastrostomy tube. It is essential to keep the esophagus ajar because swallowing could help in preventing pneumonia.

Targeted therapy is a treatment which uses drugs to target specific cancer cells, reducing the side effects from chemotherapy or radiation therapy. These medications could include monoclonal antibodies as well as other medications. There are currently clinical trials being conducted to discover new ways to treat cancers of the esophagus.

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