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작성자 Jonna 작성일23-06-20 21:46 조회37회 댓글0건

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Chronic Lymphocytic Leukemia in Railroad Workers

Railroad workers such as machinists, pipefitters and electricians have often been exposed to industrial toxic exposures, such as diesel exhaust. These toxic exposures can lead to serious diseases like mesothelioma and pulmonary issues and blood disorders.

Leukemia is a cancer that develops in the lymphatic system and bone marrow. It affects blood cells of three different types: white, red and platelets.

What is CLL?

CLL is a type of cancer that affects lymphocytes (white blood cells which fight infection). It is a result of lymphocytes that are located in the bone marrow of the soft. It may also grow elsewhere in the body, including the blood, organs like the liver and spleen as well as the blood.

CLL tends to develop slowly and doesn't cause symptoms for a long period of time. But it can get worse quickly. It's the most prevalent type of leukemia among adults.

Blood tests can help diagnose CLL. Lymph glands that are swollen in the neck, armpits, stomach or groin are the most common symptoms.

Other signs and symptoms include fatigue and a fever. Your integrated team will decide the best method of treatment.

Based on the type and stage of your CLL, you will receive different treatments. Certain types of CLL are more invasive and require more intensive treatment. Some forms of the kansas City southern railway black lung disease are less invasive and can be treated using a less intensive therapy.

The doctor will also assess the function of your lymphocytes. This is especially true if they suffer from a mutation IGVH which could impact the outcome of your treatments.

Why is CLL considered "chronic?"

CLL is caused by B lymphocytes. They are white blood cells. These cells multiply and grow faster than normal lymphocytes. They are not able to fight infections as efficiently as normal lymphocytes, and they build up in the bone marrow, causing them to crowd healthy cells out. The number of healthy platelet cells and red cells in the bone marrow and blood drop below normal levels.

Oncologists and hemologists are the doctors who treat CLL. Until recently, these specialists did not have effective treatments for this type of leukemia. The latest drugs enable patients to treat slow-growing CLL, and reduce or Kansas City Southern Railway Black Lung Disease eliminate symptoms.

It's not clear what causes most cases of CLL. It is believed that the blood-forming cells' genetic material changes (mutates). These mutations lead to abnormal lymphocytes, resulting in leukemia.

Certain people are at a higher risk of developing this disease. Your chance goes up as you age. It's more common among males than women. It's more prevalent among people of Eastern European descent. Certain studies suggest the connection between this form of leukemia and exposure to herbicides during the Vietnam War. Some of these patients may be eligible for disability compensation from the U.S. Department of Veterans Affairs.

How can CLL be diagnosed?

A blood test known as a complete blood count (CBC) typically is the first step in diagnosing CLL. It is a way to determine the amount of red blood cells and white blood cells as well as platelets in your blood. A high amount of lymphocytes is the most important sign of CLL, worker but other issues on a CBC may also signal this kind of leukemia.

A peripheral blood smear as well as flow cytometry tests can be used to check for cancerous blood cells. A doctor will remove a sample of your blood and examine it under microscope. The test is a way to determine the amount of lymphocytes present and if they exhibit other signs of leukemia like a defect referred to as del(17p).

Your doctor will inquire about your health habits and take a complete history of your family. Your symptoms and other tests will help your doctor determine if treatment is needed.

Other tests in the lab can tell you if your leukemia has spread and if it is growing slowly or quickly. They include chest Xrays and computed tomography, also known as a CT, scan. X-rays and CT scans employ a sequence of X-ray images that are that are taken from different angles. Computers then put them together to create an 3D image of bones and organs, including lymph nodes.

The night sweats, fever weight loss, pain or the sensation of fullness under the ribs indicate that your blood is too thin, or anemia. A karyotype test is a different way to measure your blood cells. This test combines a snapshot of all the chromosomes within your body. It also helps your healthcare team determine which types of chemotherapy drugs will be most effective for you.

What are the treatment options for CLL?

Your doctor will examine the white blood cells that are present in your blood. This will help your doctor decide on the treatment you require. These tests will also let your doctor know whether the kansas city southern railway laryngeal cancer has been able to spread. The primary treatments for CLL are targeted medications and chemotherapy. They are typically administered together, but they can be used separately or together with other treatments. You will need to make regular appointments with your doctor or nurse. They will ask you how you feel and if have any new symptoms between appointments.

Your treatment will depend on whether your kansas city southern railway laryngeal cancer is symptomatic and the prognosis you are given. Your prognosis will be affected by the presence of certain genetic mutations that are considered to be less favorable markers. These include del(17p), del(11q) and TP53 dysfunction and are linked to lower treatment response. [11]

Your doctor may recommend waiting until symptoms manifest or changes occur before starting any treatment. This is an option for CLL that is either symptomatic or asymptomatic. You may require other treatments depending on the symptoms. This includes the anti-CD20 drug bendamustine. This medication can cause side effects like diarrhea, nausea, vomiting and fatigue. To decrease the risk of adverse effects the doctor will prescribe appropriate premedication prior the administration of this medication. It is also possible to use a tyrosine-kinase inhibitor, such as ibrutinib (also called acalabrutinib), Idelalisib (also called duvelisib), or idelalisib. These medications block the enzyme tyrosine kinase which causes stem cells to create more white blood cells that your body needs.

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