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작성자 Deena 작성일23-06-24 12:34 조회3회 댓글0건

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Esophageal Cancer (EAC) and Esophageal Sarcoma (ESCC) in Canada

Since the mid 1980s, rates of EAC have been rising in Canada while ESCC has been declining. These opposite trends could be due to changing patterns of cigarette smoking and diet, or other factors.

Five-year relative survival for individuals diagnosed with esophageal cancer is low (13 percent). The rates vary based on the morphology of the tumor and the location of the tumour.

Risk Factors

Esophageal cancer is a major cause of cancer deaths around the world with more than 604,000 newly diagnosed cases and 544,000 deaths in 2017. About 70% of patients are male, and tend to be more prevalent for older people. The incidence and mortality rates vary depending on the region. The most severe rates are found in Eastern Asia (especially China) while the lowest rates are in Western sub-Saharan Africa.

Overall, the global age-standardised incidence, mortality and DALY rates for esophageal squamous cell carcinoma (ESCC) have been decreasing since 1990; however, this trend is not consistent across canadian pacific all countries/territories. These changes are largely a result of improved diagnosis and treatment, but also reflect the changing climate in the world which has an increase in exposure to alcohol and smoking tobacco.

In addition, a number of risk factors contribute to the development of esophageal carcinoma (EAC). A few of them are an underlying gastro-oesophageal disease, smoking, drinking alcohol and chewing tobacco too much or not maintaining a good oral hygiene, eating a diet deficient in vegetables and fruits, and being overweight. A hereditary predisposition and Barrett's Esophagus are also possible risk factors.

The specific esophageal canadian pacific pancreatic cancer-related DALY is calculated using the incidence and prevalence rates at the country level as well as an individual weighting factor for each canadian pacific chronic obstructive pulmonary disease in order to estimate the sequelae-specific disability. For more information, please refer to the Methodology Section of the Technical Report.

Diagnosis

The rates of survival and incidence for esophageal tumors are low. In Canada the five-year relative survivor rate is 13 percent. This is the lowest survival rate.

Esophageal cancers are classified into two classes: esophageal squamous cell carcinomas (ESCC) and esophageal cancers called adenocarcinomas (EAC). The tumors that are located in the upper portion of the esophagus could be classified as squamous-cell tumors, while those that are found in the lower area of the esophagus could be adenocarcinomas. A biopsy is typically required to confirm the diagnosis. The procedure used for this is called an esophagogastroduodenoscopy. It involves passing a flexible, camera-equipped tube into the throat in order to examine the esophageal walls. The biopsy is then taken from the lesion to test for malignancy.

Rates of esophageal cancer have been steady in Canada since the mid-1980s, with rates for EAC slightly higher than those for ESCC. Between 1986 and 2006, the prevalence of EAC increased by two-thirds, while ESCC decreased by a third. The rise in the incidence of EAC could be due to increases in gastroesophageal reflux disease and obesity. Smoking cessation is likely to be the cause of the decline in ESCC.

The rate of incidence and survival vary across the nation based on the morphology of the tumor and location in the anatomical factors. For instance, the rates of EAC have increased dramatically in British Columbia and Ontario, however, rates for ESCC have declined in these areas.

Treatment

The cancer may be located in the outer layer (squamous-cell carcinoma) or in the muscle and connective tissues in the interior (esophageal-squamous cancer). These cancers are usually treated through surgery. If the canadian pacific stomach cancer has spread to adjacent lymph nodes and tissues, it's harder to cure. Patients suffering from stage II esophageal cancer can be treated with endoscopic ablation or radiation therapy. They should also be followed closely by endoscopy to check for any indications of cancer recurring.

Chemotherapy employs drugs to kill cancer cells or stop them from growing. The drugs can be taken orally or injected directly into a muscle or vein. They can be given without or with radiation. When chemotherapy is given using radiation, it is called chemotherapy therapy.

To keep the esophagus open during radiation treatment, a plastic tube can be placed. This is known as a Gastostomy tube. It is important to keep the esophagus in good condition because swallowing can help to prevent pneumonia.

Targeted therapy is a method of treatment that utilizes drugs to target certain cancer cells, thus reducing the adverse effects of chemotherapy or Canadian pacific stomach cancer radiation therapy. These medicines may include monoclonal antibodies as well as other drugs. Clinical trials are currently underway to discover new treatments for cancer of the esophageal lining.

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